Visco-supplementation such as Hyalgan or Euflexxa is used to treat knee pain in patients with joint inflammation (osteoarthritis). It is usually used in patients who have not responded to other treatments such as acetaminophen, NSAIDs, exercise, or physical therapy. Hyaluronate (also known as hyaluronan) is similar to a substance that occurs naturally in the joints. It may work by acting as a lubricant and shock absorber in the joint, helping the knee to move smoothly, thereby lessening pain.

Your doctor will give this medication by injection into the affected joint, usually once a week.  The skin around the injection site will be thoroughly cleaned with Povidone Iodine and isopropyl alcohol (chlorhexdine will be used for Iodine allergy).  The doctor will then use ultrasound guidance to place the needle precisely at the injection site.

After receiving an injection of hyaluronate, you should avoid any activities that put stress on your knee (such as jogging, tennis, heavy lifting, standing on your feet for more than an hour) for 48 hours.

Also, after the injection, you may experience increased pain and swelling in the knee at first. If the pain or swelling continues or worsens, talk to your doctor promptly.

It is important to have this medication injected on schedule. It may take up to 3 injections before the full benefits of this medication occur.

Tell your doctor if your condition persists or worsens.